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A reaction with another antigout drug, allopurinol, may cause a rash. The mechanism is unknown and pharmacokinetic studies with hydrochlorothiazide have not demonstrated any effects on the disposition of allopurinol or oxipurinol (its major metabolite). Ask your health care provider if Allopurinol may interact with other medicines that you take. The product of methylation, 2-amino-6-methylthiopurine, is also substantially less active and less toxic than Thioguanine and its formation is likewise unaffected by the presence of allopurinol. Allopurinol will not relieve a gout attack that has already started.
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